GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1000940 | 1 | rs58351927 | chr17:5297038 | NLRP1 | chr17:5404719-5487832:- | -0.22 | -4.58 | 5.92E-6 | Body mass index |
| THCA | cis | rs1000940 | 1 | rs58351927 | chr17:5297038 | RABEP1 | chr17:5185558-5289131:+ | -0.12 | -3.6 | 0.000354 | Body mass index |
| THCA | cis | rs583583 | 1 | rs583583 | chr1:147083114 | ACP6 | chr1:147119168-147142634:- | 0.75 | 15.95 | 3.3E-46 | Schizophrenia (negative symptoms) |
| THCA | cis | rs2241437 | 1 | rs58365138 | chr2:86213105 | POLR1A | chr2:86253453-86333278:- | -0.29 | -3.9 | 0.000112 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| THCA | cis | rs2241437 | 1 | rs58381542 | chr2:86203685 | POLR1A | chr2:86253453-86333278:- | -0.32 | -4.38 | 1.45E-5 | Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) |
| THCA | cis | rs2129782 | 1 | rs58399951 | chr8:89437490 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs12908161 | 1 | rs58416181 | chr15:85264461 | GOLGA6L5 | chr15:85047738-85060078:- | -0.15 | -3.84 | 0.000138 | Schizophrenia |
| THCA | cis | rs12908161 | 1 | rs58416181 | chr15:85264461 | LOC388152 | chr15:84867600-84898920:- | -0.47 | -7.96 | 1.24E-14 | Schizophrenia |
| THCA | cis | rs12908161 | 1 | rs58416181 | chr15:85264461 | NMB | chr15:85198362-85201802:- | 0.36 | 7.48 | 3.54E-13 | Schizophrenia |
| THCA | cis | rs12748152 | 1 | rs58421016 | chr1:27070529 | ZDHHC18 | chr1:27153201-27182207:+ | 0.8 | 8.6 | 1.15E-16 | HDL cholesterol;Triglycerides;LDL cholesterol |
| THCA | cis | rs515910 | 1 | rs584309 | chr10:105956776 | C10orf79 | chr10:105889647-105992120:- | 0.25 | 7.93 | 1.54E-14 | Attention deficit hyperactivity disorder |
| THCA | cis | rs6496667 | 1 | rs58436485 | chr15:90900633 | IQGAP1 | chr15:90931473-91045475:+ | 0.15 | 4.63 | 4.67E-6 | Rheumatoid arthritis |
| THCA | cis | rs6496667 | 1 | rs58436485 | chr15:90900633 | TTLL13 | chr15:90792764-90815443:+ | 0.27 | 4.57 | 6.24E-6 | Rheumatoid arthritis |
| THCA | cis | rs2129782 | 1 | rs58453379 | chr8:89438243 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs4038131 | 1 | rs58453750 | chr2:17778329 | GEN1 | chr2:17935162-17966632:+ | 0.58 | 7.52 | 2.66E-13 | Psychosis and Alzheimer's disease |